Depends on how good your fabrication skills are.
There are NO GM 12 bolt rear ends that bolt into a Dakota without fabrication.
And if you really mean "a 9.25 with disc brakes", consider you'll still have to do the shock mounts on a 2000-2003 Dakota/Durango rear axle with disc brakes; and it's 6 lug.
OTOH, you can find 8.25 disc brake conversion kits ( one that I found rated well online is
Ram Man / Shop / MOPAR / DODGE 8.25" REAR DISC CONVERSION KIT (10.5" Drilled & Slotted Rotors) (therammaninc.com) ), swap to 1987-1990 5 lug rear axles, and build up your current rear axle and you're golden (no fabrication skills, just mechanical ability).
(BTW - the "10 bolt and 12 bolt" nomenclature is for a GM rear end; try calling it by the Mopar name, helps some when you go looking. 8.25 / 8.75 / 9.25 are the sizes, and 8.75 was never offered, being depreciated by the time the Dakota came out.)
The 8.25 is also called, for some ratios, a 8.375 or 8 3/8" rear end. They pick size by the diameter of the ring gear.
For the front, as I mentioned earlier, a 87-90 front rotor/hub combo will fit and work fine. If you have good fabrication skills, you may be able to remove the rotor from the combo (don't know, haven't tried), and machine out a Mustang rotor's center hub to fit.
DO use a high quality bearing set (I'm partial to Timken, prefer the German ones myself, but they're not the ONLY good game in town) and top line lube (again, I'm partial to the moly graphite lubes; YMMV depending on exactly what you find out on the track.)
For the rear end - again, I like rebuildable, but if it's going to be a drag truck, a locker may be your best bet. (Don't want a locker on the street, defeats the whole purpose of a differential).
You'll have to remove the ABS equipment, and also use a different proportioning valve, if you go disc in the back.
RwP